Targeting & Biology
Targeted delivery of nanoparticles is an area that has been intensely investigated for decades. Methods for delivering a drug at a high concentration to a specific organ or tissue in the human body are meant to enhance efficacy while reducing unwanted side effects and toxicity. Targeted drug delivery has a role to play in the delivery of many if not all drugs, but targeted delivery systems are absolutely critical for delivery of nucleic acid-based agents such as siRNA and CRISPR-Cas technology.
Unlike many other nanoparticle-based delivery systems, exosomes are easily modified to contain targeting entities to enable tissue- and organ-specific delivery. Evox has created substantial proprietary technology to modify exosomes using various targeting strategies to facilitate targeted drug delivery to organs of interest, not least to the brain and the central nervous system. Our R&D teams are in constant pursuit of novel targeting strategies for enhancing exosome-mediated delivery to tissues of interest and combining this with the inherent biology of exosomes to further drive optimal in vivo behavior.