Evox Technology

Protein Engineering

A key component of Evox’s technology platform relates to engineering of exosome proteins for optimized loading of drug cargos and targeting moieties into and onto exosomes. 

Evox’s proprietary protein engineering technology enables loading of protein therapeutics and targeting moieties onto the surfaces of exosomes, which enables tissue targeting and display of therapeutic proteins. Additionally, Evox protein engineering strategies comprise methods for loading the inside of exosomes and extracellular vesicles with various types of drug cargo, notably therapeutic proteins and nucleic acids. This modulation of the protein composition of exosomes is key to developing potent therapeutics harnessing both the native effects of exosomes and the specificity and affinity of conventional biologics, such as monoclonal antibodies and siRNAs.