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Scientist – Upstream Process Development


at Evox Therapeutics

Join Our Team

MAIN PURPOSE OF JOB                                                                                                                         

We have an exciting opportunity for an experienced Upstream Process Development Scientist to join our growing CMC- Upstream Process Development Team. S/he will play a vital role working on projects to design, develop, optimise, characterise and scale-up mammalian cell culture processes for the manufacture of exosome therapeutics. S/he will work on cell culture processes across a wide range of scales from shake flask, ambr15, ambr250 through to multi-litre suspension culture and scale-up to 50/200L single use bioreactors (SUB).

KEY ACCOUNTABILITIES

Design, develop and optimise mammalian cell culture processes suitable for manufacturing.

Work with production scales/systems such as shake flask, ambr15, ambr250, 2L through to 50L and 200L scale SUB’s.

Develop and optimise processes based on batch, fed-batch or perfusion modes of operation, including basal media and feed development and optimisation.

Exploit Design of Experiments (DoE) to aid efficient process development.

Work collaboratively with scientists in Cell Line Development, Downstream Process Development, Analytical Development and Pre-clinical Manufacturing.

Ensure experiments are completed and maintained according Company data integrity policies and procedures.

Troubleshoot equipment and methods within the process development and manufacturing teams.

Present data and conclusions to Evox CMC and Research teams.

Contribute to the maintenance and housekeeping of a safe laboratory working environment.

PERSON SPECIFICATION

An ambitious scientist seeking a role that ‘makes a difference’ and relish the opportunities and challenges of working in rapidly expanding biotechnology company.

Want to apply your skills and knowledge to a new and novel area of medicine development.

Have great communication skills and ability to present own innovative ideas and solutions.

Experience & knowledge

BSc/MSc in a Biological Science, Biochemical Engineering or related discipline.

4-5 years post graduate cell culture process development experience, gained in an industrial laboratory, for example biologics and/or viral-gene therapy field.

Experience of working with automated systems such as ambr15/250 and/or use of DoE would be an advantage but not essential.

KEY BEHAVIOURAL ATTRIBUTES – ALL STAFF

People with Purpose – We are innovative and creative in the way we work and deliver. We treat each other with respect and dignity and work collaboratively to learn from each other’s strengths.

Driven to Deliver – We strive to deliver our objectives, and then look for our next challenge. We recognise our achievements and celebrate our successes.

Agile and Accountable – We respond to challenges impacting our progress and find creative and innovative solutions to overcome obstacles. We are brave and not afraid to change our approach to achieve a positive outcome in optimum time.

Candid and Constructive – We communicate with honesty and transparency throughout the team.  We value giving and receiving constructive feedback to each other and our partners.

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