We are seeking an inquisitive and highly motivated and enthusiastic Research Associate with strong attention to detail to facilitate the early development of novel therapeutics which could become future therapies for patients suffering from rare diseases. The role will provide a rare opportunity to carry out research which will underpin the future development of a growing company. Due to the nature of our organisation, a Research Assistant joining at entry level will have the opportunity to gain experience in multiple aspects of drug development.
Accordingly, we are looking for an individual who is an exemplary team player, who will provide the driving force to get projects off the ground, thrive in a start-up environment, and be able to innovate and share in the accomplishments of others.
This position is based at Evox Therapeutics facility at the Oxford Science Park, Oxford, UK and reports to the Principal Scientist, Rare Disease.
- Generate data on the amenability of different proteins for loading into exosomes, apply novel protein engineering approaches to these to optimise this process.
- Develop new techniques which can be used to interrogate how cargoes are loaded into exosomes.
- Provide functional readouts of cargo delivery by utilising and developing In vitro models of rare diseases.
- Work collaboratively across different research departments, with Cell Line Development, Upstream Process Development, Analytical Development to ascertain which disease targets are most applicable to our platform.
- Share data within the rare disease team and across the broader organisation as both written reports and presentations.
- Deliver research activities which are underpinned by quality procedures and best practice documentation.
- Ensure a healthy and safe working environment and compliance to GMO/ACDP requirements.
Education and Qualifications:
- BSc/MSc in Cell Biology, Biochemistry, Biotechnology, Biological Sciences, Biochemical Engineering or a related field.
A highly competent researcher with strong hands-on technical ability who can demonstrate the following;
- Ability to quickly acquire new skills and progress to independent working.
- Good conceptual, analytical thinking, problem solving, and organisational skills.
- Ability to work in a high paced team environment, meet deadlines, and prioritise work from multiple projects.
- Strong interpersonal and communication skills with demonstrated ability to work within a team environment.
- Ability to provide the driving force to move a project forward.
Experience & knowledge
- Strong basic hands on laboratory skills and technical knowledge to underpin this.
- Molecular biology expertise and familiarity with generation of protein constructs.
Experience of routine analytical techniques such as SDS-PAGE, Western Blotting and biochemical assays.
- Experience of ELISA, cell based assays, NTA and flow cytometry.
- Knowledge of exosome biology, purification and analysis.
- Knowledge of the biology of Lysosomal Storage Disorders or Inherited Metabolic Diseases.
KEY BEHAVIOURAL ATTRIBUTES – ALL STAFF
People with Purpose – We are innovative and creative in the way we work and deliver. We treat each other with respect and dignity and work collaboratively to learn from each other’s strengths.
Driven to Deliver – We strive to deliver our objectives, and then look for our next challenge. We recognise our achievements and celebrate our successes.
Agile and Accountable – We respond to challenges impacting our progress and find creative and innovative solutions to overcome obstacles. We are brave and not afraid to change our approach to achieve a positive outcome in optimum time.
Candid and Constructive – We communicate with honesty and transparency throughout the team. We value giving and receiving constructive feedback to each other and our partners.