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Principal Scientist – Pharmacology

at Evox Therapeutics

Join Our Team

The Principal Scientist Pharmacology will help review and oversee the implementation of internal and external pharmacology studies looking at the biodistribution, pharmacokinetics, efficacy, and safety of drug-loaded engineered exosomes. Studies will be carried out using both internal and external resources. The Principal Scientist with assistance from others in the R&D team will help design and analyse the data from these studies. When working with external providers, the Principal Scientist will be involved in establishing an agreed study protocol, getting quotes from prospective vendors, and ensuring the timely execution of those studies. Upon receipt of data, this individual will ensure that the data is analysed and appropriate study reports generated.

The Principal Scientist will also take responsibility for overseeing and building an internal Evox Pharmacology group to develop and validate internal assays (ADA, PK, etc.) needed to support analysis of pre-clinical and clinical samples. This individual will be expected to perform hands-on laboratory work carrying out ex vivo analysis on samples as well as supervising others.

This position is based at Evox Therapeutics facility Oxford Science Park, and reports to the Head of Research.

Key Responsibilities:

  • Key point of contact for internal and external pharmacology studies looking at the distribution, pharmacokinetics, efficacy, and safety of drug-loaded engineered exosomes
  • Carry out hands-on work to develop and run in-house assays to measure anti-drug antibodies and the pharmacokinetics of exosomes
  • Develop internal assays to the point where they can be transferred, validated, and run by external providers or run in-house
  • Authoring and reviewing internal and external pharmacology protocols and reports
  • Supervise and mentor pharmacology scientists and technicians
  • Subject matter expert with knowledge of the technical/scientific methods used in a GLP-compliant laboratory
  • Execute good documentation practice
  • Build relationships with vendors and contractors
  • Additional responsibilities/tasks may be assigned

Educational Requirements:

  • Minimum PhD in pharmacology or relevant biological sciences

Experience and Skill Requirements:

Training and experience will be appropriate to specific job requirements. The following
categories will be assessed in each case:

  • At least 8+ years direct laboratory experience in pharmacology with PhD
  • Pharmaceutical/biotech industry experience required with background in development of biologics and/or advanced cell/gene therapies
  • Demonstrated ability to develop and validate GLP-regulated pharmacology assays needed to support clinical studies
  • Experience overseeing and reviewing external pharmacology studies
  • Knowledge and experience drafting and submitting pharmacology-related documents needed for CTA/IND submission
  • Data analysis with statistical methods
  • Ability to work well in a team
  • Effective communication skills
  • Good organisational skills
  • Supervisory experience

Full-time 40 hours per week

**Strictly no agencies please, as we operate a closed preferred supplier list**

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