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Cell Line Development Scientist II

at Evox Therapeutics

Join Our Team

An exciting opportunity for an experienced and ambitious cell biologist / molecular biologist to join a rapidly growing CMC group delivering a modular platform for clinical translation of a range of exosome-based therapeutics. Working closely with Upstream Process Development group and research group the Cell Line Development Scientist develops and establishes immortalised stable cell lines which will ultimately be used for engineered exosome production to enable production of clinical trial material.

Summary of Job Description:

The Cell Line Development Scientist will assist in identifying/designing vectors for stable cell line generation, cloning, maxiprep, primary cell culture, transfections, single cell cloning, cell characterisation, cell line stability etc. experience with design of experiments (DoE) software for planning complex experiments, use of automated Ambr15 system, and spent media analyser / Flex2 would be highly advantageous. The Scientist will also work across functional groups – up-stream process development and in-process analytics. The Scientist will be required to perform procedures and experiments under supervision, and these may range from simple to complex operations. The Scientist will be required to use his/her knowledge of cell biology theory, techniques and equipment to interpret and perform experimental protocols and studies for the purposes of reporting and analysing data and developing new or modifying existing processes or assays.

This position is based at Evox Therapeutics facility based in the Oxford Science Park, and reports to the Principal Scientist in CMC department.

Key Responsibilities/Experience:

  • Cell line development
  • Experience of experimental design, e.g. using DoE software
  • Experienced in executing experiments using Ambr 15
  • Perform the following established procedures including, but not limited to, cell culture (adherent / Suspension), and exosome harvest.
    • Produce exosome harvest to support downstream process development and process characterisation.
    • Adhere to good documentation practices.
    • Good understanding of GLP / GxP
  • The Development Scientist will plan their daily work activities, (e.g. the operation of equipment, cell culture, data analysis and report writing) based on experimental plans and time scales set out by their supervisor.
  • The Development Scientist will also be required to recognise, record and inform their supervisor of issues pertaining to particular operational problems or scientific/technical issues relating to their daily work activities.
  • Offer suggestions for resolution of technical issues based on experience. The Development Scientist will be expected to show creativity in resolving issues.
  • The Development Scientist will be required to communicate verbally and in writing within the CMC group.
  • Present scientific data at internal CMC meetings.

Other Responsibilities:

  • Write/revise/review SOP’s, risk assessments, protocols and reports.
  • Perform laboratory tasks including general housekeeping, equipment monitoring and maintenance.
  • Troubleshoot equipment and methods within the Process Development and Manufacturing teams.
  • Additional responsibilities/tasks may be assigned.

Educational Requirements:

  • BSc/MSc or Ph.D in Biological Sciences/Cell Biology

Experience and Skill Requirements:

Education, training and experience will be appropriate to a specific job description. As a guideline the following may be considered:

  • 2-5 years’ experience in a relevant work environment.
  • Computer literacy (including MS Word and Excel).
  • Ability to work well as part of a multi-disciplinary team.
  • Effective communication skills.
  • The Scientist should be capable of receiving and correctly following instructions and seek clarification if instructions are unclear.
  • Experience with mammalian cell culture.
  • Experience of operating Ambr15 for clone selection, media optimisation and process development would be advantageous.

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