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Publications

Publications of interest

As a science-led organisation, Evox is working at the leading edge of exosome therapeutics research and development. Our scholarship manifests itself in peer-reviewed publications and review articles published in leading journals. Below are some recent examples of research published by Evox and its collaborators, as well as articles featuring our pioneering work:

 

 

Engineered exosomes: a transformative therapeutic modality (Review article)
Jones et al., Cell & Gene Therapy Insights, 2022

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models
Liang et al., Journal of Extracellular Vesicles, 2022

Identification of storage conditions stabilizing extracellular vesicles preparations
Görgens et al., Journal of Extracellular Vesicles, 2022

Description and optimization of a multiplex bead-based flow cytometry method (MBFCM) to characterize extracellular vesicles in serum samples from patients with hematological malignancies 
Li et al., Cancer Gene Therapy, 2022

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles (Nature subscription required)
Gupta et al., Nature Biomedical Engineering, 2021

Optimised Electroporation for Loading of Extracellular Vesicles with Doxorubicin
Lennaárd et al., Pharmaceutics, 2021

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
Dar et al., Nature Communications, 2021

Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles
Bost et al., Advanced Healthcare Materials, 2021

Dosing extracellular vesicles (Review article)
Gupta et al., Advanced Drug Delivery Reviews, 2021

The power of imaging to understand extracellular vesicle biology in vivo
Verweij et al., Nature Methods, 2021

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceição et al., Biomaterials, 2021

Functional extracellular vesicles aplenty (Nature subscription required)
Zickler et al., Nature Biomedical Engineering, 2020

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta et al., Journal of Extracellular Vesicles, 2020

Extracellular vesicles as drug delivery systems: Why and how? (Review article)
Elsharkasy et al., Journal of Extracellular Vesicles, 2020

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA
de Jong et al., Nature communications, 2020

Exosome redux (Nature subscription required)
Zipkin, M., Nature Biotechnology, 2019

Advances in therapeutic applications of extracellular vesicles (Review article)
Wiklander et al., Science Translational Medicine, 2019

Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material
Görgens et al., Journal of Extracellular Vesicles, 2019

Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging
Corso et al., Journal of Extracellular Vesicles, 2019

Tangential Flow Filtration with or Without Subsequent Bind-Elute Size Exclusion Chromatography for Purification of Extracellular Vesicles
Nordin et al., Methods in Molecular Biology, 2019

Systematic methodological evaluation of a multiplex bead-based flow cytometry assay for setection of extracellular vesicle surface signatures
Wiklander et al., Frontiers in Immunology, 2018

Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD
Coenen-Stasset al., Molecular Therapy Nucleic Acids, 2018

Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography
Corso et al., Nature Scientific Reports, 2017

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles
O'Loughlin et al., Molecular Therapy, 2017

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER
Heusermann et al., Journal of Cell Biology, 2016

Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods
Baranyai et al., Plos One, 2015

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
Wiklander et al., Journal of Extracellular Vesicles, 2015

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Nordin et al., Nanomedicine, 2015

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
Cooper et al., Movement Disorders, 2014

Extracellular vesicles: biology and emerging therapeutic opportunities (Review article)
El Andaloussi et al., Nature, 2013

Exosome-mediated delivery of siRNA in vitro and in vivo
El-Andaloussi et al., Nature Protocols, 2012

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti et al., Nature Biotechnology, 2011